Efficacy of Amphotericin-B, Clinicopathologic Variables and Oxidative Stress Markers in three Staffordshire Bull Terrier Dogs with Visceral Leishmaniasis

Basak HANEDAN, Mehmet Kazim BORKU, Yunusemre OZKANLAR, Ali Evren HAYDARDEDEOGLU, Serkal GAZYAGCI, Ahmet AYDIN, Seckin OZKANLAR
899 121

Öz


 Bu   çalışmada   visseral   Leishmaniasis’li   (VL)   üç   Staffordshire   Bull   Terrier   köpekte   Leishmania   enfeksiyonu   ve   AMB  (amfoterisin-­‐B)   tedavisinin   hematolojik,   biyokimyasal   ve   oksidatif   stres   parametreleri   üzerine   etkilerini   değerlendirmek  amaçlandı.   Bu   köpekler   kilo   kaybı,   halsizlik   ve   deri   lezyonları   ile   kliniğe   getirildi.   Kanin   kala-­‐azar   test   kiti   VL’li   köpeklerde  pozitifti.  Visseral  Leishmaniasis’li  olgulara  AMB  0.6-­‐1.5  mg/kg/hafta  dozunda  4  ay  süre  ile  uygulandı.  Leishmania  etkenleri  olgu  1  ve  2’de  ALT  düzeyinde  artışa  bağlı  olarak  karaciğer  hasarına,  olgu  3’te  eritrosit,  hemoglobin  ve  hematokrit  düzeyde  azalmaya  ve  MDA’da  artışa  ve  GSH-­‐Px’de  azalmaya  neden  oldu  fakat  VL’li  köpeklerde  normal  üre  ve  kreatinin  düzeyine  bağlı  olarak   böbrek   fonksiyonlarını   etkilemedi.   AMB   tedavisine   kademeli   yanıt   gözlendi.   Tedavi   seyrinin   sonunda   VL’li   olgular  klinik   olarak   iyileşti.   Sonuç   olarak   6   ay   süre   ile   takipte   klinik   nüks   olmamasına   bağlı   olarak   visseral   Leishmaniasis’i   tedavi  etmek  için  4  ay  süreli  AMB  uygulamasının  etkili  olabileceği  kanısına  varıldı.  

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DOI: http://dx.doi.org/10.17094/avbd.44294

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