Deneysel serebral iskemi'de Lidokain'in etkileri

Erhan TAKÇI, Hakan Hadi KADIOĞLU, İbrahim TAHMAZOĞLU, İsmail Hakkı AYDIN
468 120

Öz


Bu çalışmada tek taraflı karotid arter ligasyonu ile oluşturulan deneysel hemisferal iskemi üzerine Lidokain'in etkisi araştırıldı, Halotan inhalasyonu ile anestetize edilen 20 farede sağ a. Carotis communis (ACCo) bağlandı. ACCo'nun ligasyonundan 30 dakika önce çalışma grubundaki 10 fareye 5 mg/kg'dan intravenöz olarak Lidokain, kontrol grubundaki 10 fareye aynı hacimde % 0,2 NaCI verildi. Ligasyondan 6 saat sonra her iki gruptaki denekler sakrifiye edilerek beyinleri çıkarıldı. Bu süre içerisinde deneklerdeki nörolojik değişiklikler araştırıldı, belirlenenler kaydedildi. Çıkarılan beyin örnekleri % 10'luk formaldehit içerisinde tesbit edildikten sonra, kesitler alınarak histolojik olarak değerlendirildi. Bu çalışmanın sonunda, istatistiksel olarak Lidokain ile tedavi edilen grupta meydana gelen iskemik nöronal değişikliklerin kontrol grubundan daha hafif olduğu görüldü. Buna dayanılarak Lidokain'in iskemide koruyucu etkisinin olduğu kanısına varıldı.

Anahtar kelimeler


Nöroproteksiyon,Koruyucu etki,Beyin iskemisi,Lidokain,Fare,Hastalık modelleri, hayvan,Karotis arterleri

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Referanslar


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