SİKLOSPORİN-A VE AMLODİPİN KULLANIMINA BAĞLI DİŞETİ BÜYÜMESİNİN ND:YAG LAZERLE TEDAVİSİ: OLGU SUNUMU

Gülnihal Emrem Doğan, Ebru Sağlam, Mehmet Cankat Kara, Turgut Demir
391 231

Öz


Organ transplantasyonlarında kullanılan temel bir immünosüpresan olan siklosporin-A (Cs-A) ve antihipertansif amlodipinin kullanımına bağlı oral komplikasyonlar gelişebilmektedir. Bu komplikasyon- ların en yaygın olanlarından biri dişeti büyümeleridir. Bu olgu, böbrek transplantasyonu nedeni ile uzun dönem Cs-A ve amplodipin kullanımı sonucu dişeti büyüme şikayeti gelişen bir hastanın tedavi öncesi ve sonrası klinik durumunu ortaya koymaktadır. Sunulan vakada aşırı büyüyen dişeti dokularında Nd: YAG lazerle yapılan cerrahi işlemi takiben dikkatli plak kontrolü ile dişeti dokusunda yeterli ölçüde iyileşme sağlanmıştır. Cerrahide Nd: YAG lazer kullanımı cerrahi sonrası gelişebilen kanama, ağrı gibi komplikasyonları azaltmıştır.

Anahtar Kelimeler: Siklosporin-A, Amlodipin, Dişeti Büyümesi, Nd:YAG Lazer


Anahtar kelimeler


Siklosporin-A, Amlodipin

Tam metin:

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DOI: http://dx.doi.org/10.17567/dfd.67582

Referanslar


Lafzi A, Farahani RM, Shoja MA. Amlodipine- induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal,2006, 11: E480-2.

Eggerath J, English H, Leichter JW. Drug- associated gingival enlargement: case report and review of aetiology, management and evidence- based outcomes of treatment. J N Z Soc Periodontol,2005: 7-14.

Kara c, Yağız H, Zihni M. Nifedipin tedavisine bağlı ortaya çıkan dişeti büyümesi (Olgu Sunumu). Atatürk Üni Diş Hek Fak Derg 2006;16(1):59-62.

Callaghan CJ, Bradley JA. Current status of renal transplantation. Methods Mol Biol,2006, 333: 1- 28.

Gourishankar S, Halloran PF. Late deterioration of organ transplants: a problem in injury and homeostasis. Curr Opin Immunol,2002, 14: 576- 83.

Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med,2000, 342: 605-12.

Lopez-Pintor RM, Hernandez G, de Arriba L, Morales JM, Jimenez C, de Andres A. Amlodipine and nifedipine used with cyclosporine induce different effects on gingival enlargement. Transplant Proc,2009, 41: 2351-3.

Seymour RA, Ellis JS, Thomason JM, Monkman S, Idle JR. Amlodipine-induced gingival overgrowth. J Clin Periodontol,1994, 21: 281-3.

Camargo PM CF, Takei HH. , Treatment of gingival enlargement. 11 ed.; St. Louis, Missouri, 2011; p 556-61.

Mattson JS, Blankenau R, Keene JJ. Use of an argon laser to treat drug-induced gingival overgrowth. The Journal of the American Dental Association,1998, 129: 78-83.

Loe H, Silness J. Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontol Scand, 1963, 21: 533-51.

Silness J, Loe H. Periodontal Disease in Pregnancy. Ii. Correlation between Oral Hygiene and Periodontal Condtion. Acta Odontol Scand,1964, 22: 121-35.

Radwan-Oczko M, Boratynska M, Klinger M, Zietek M. Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. Ann Transplant,2003, 8: 57-62.

Hernandez G, Arriba L, Frias MC, de la Macorra JC, de Vicente JC, Jimenez C, de Andres A, Moreno E. Conversion from cyclosporin A to tacrolimus as a non-surgical alternative to reduce gingival enlargement: a preliminary case series. Periodontol,2003, 74: 1816-23. J

Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol,1999, 70: 63-7.

Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol,1997, 68: 676- 8.

Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet, 1993, 341: 1102-3.

Lin YT, Yang FT. Gingival enlargement in children cyclosporine transplantation. J Periodontol,2010, 81: 1250-5.

Thomas DW, Newcombe RG, Osborne GR. Risk factors in the development of cyclosporine-induced gingival overgrowth. Transplantation,2000, 69: 522-6.

Nurmenniemi PK, Pernu HE, Laukkanen P, Knuuttila ML. Macrophage subpopulations in gingival overgrowth induced by nifedipine and immunosuppressive medication. J Periodontol, 2002, 73: 1323-30.

Lima RB, Benini V, Sens YA. Gingival overgrowth in renal transplant recipients: a study concerning prevalence, severity, periodontal, and predisposing factors. Transplant Proc,2008, 40: 1425-8.

Aimetti M, Romano F, Priotto P, Debernardi C. Non-surgical periodontal therapy of cyclosporin A gingival overgrowth in organ transplant patients. Clinical results at 12 months. Minerva Stomatol, 2005, 54: 311-9.

Darbar UR, Hopper C, Speight PM, Newman HN. Combined treatment approach to gingival overgrowth due to drug therapy. Periodontol,1996, 23: 941-4. J Clin

Kara C. Evaluation of patient perceptions of frenectomy: a comparison of Nd:YAG laser and conventional techniques. Photomed Laser Surg, 2008, 26: 147-52.

Pogrel MA, Yen CK, Hansen LS. A comparison of carbon dioxide laser, liquid nitrogen cryosurgery, and scalpel wounds in healing. Oral Surg Oral Med Oral Pathol,1990, 69: 269-73.

White JM, Goodis HE, Rose CL. Use of the pulsed Nd:YAG laser for intraoral soft tissue surgery. Lasers Surg Med,1991, 11: 455-61.