EVALUATION OF INFLAMMATORY CYTOKINE AND PLASMA TITANIUM LEVELS IN DENTAL IMPLANT TREATED PATIENTS

Süleyman Kılıç, Hakkı Oğuz Kazancıoğlu, Ümit Küçüksezer, Günnur Deniz, Gülsüm Ak
1.467 413

Öz


Amaç: Bu çalışmada kanda Titanyum (Ti) dental implantların korozyon ürünlerinin ve de fizyolojik korozyonu etkileyen inflamatuar sitokin sekresyonunun Ti implantlar üzerine etkisinin değerlendirilmesi amaçlanmıştır. 

Metod: Kırk hasta iki gruba ayrıldı. Group 1 Microtextured Ti yüzeye sahip Zimmer Tapered Screw-Vent implantlar ile tedavi edildi. Group 2 Hidroksi Apatit yüzeye sahip Implant Direct ScrewPlant implant sistemi ile tedavi edildi. Bütün implantlar mandibular posterior bölgeye yerleştirildi. İmplantasyon öncesi ve cerrahiden 4 ay sonar periferal kan örnekleri alındı ve analiz edildi.

Bulgular: Çalışma gruplarının hepsinde istatiksel olarak anlamlı olmasa da artmıştır (p>0.05). Bütün gruplar implant uygulaması öncesi ve sonrası serum Ti seviyeleri karşılaştırıldığında serum IL-1 beta (p<0.05) düzeyi dışında Ti, IL-6, IL-10, ya da TNF-alfa (p>0.05) seviyelerinde artma saptanmamıştır.

Sonuç: Serum Ti seviyesi ile implant uygulanması arasında bir ilişki saptanmamıştır.

Anahtar Kelimeler: Stokin, korozyon, dental, implant, titanyum


Anahtar kelimeler


Stokin, korozyon, dental, implant, titanyum

Tam metin:

PDF


DOI: http://dx.doi.org/10.17567/dfd.11646

Referanslar


Kazancioglu HO, Cakir O, Koyuncuoglu G, Ciftci A, Ak G. Oral Findings and Health Status among Turkish Geriatric Patients with or without Dementia. http://dx.doi.org/10.1016/j.ijge.2012.11.012.

McGarry S, Morgan SJ, Grosskreuz RM, Williams AE, Smith WR. Serum titanium levels in individuals undergoing intramedullary femoral nailing with titanium implant. J Trauma 2008;64:430-3.

Chaturvedi TP. An overview of the corrosion aspect of dental implants. Indian J Dent Res 2009;20:91-8.

Bianco PD, Ducheyne P, Cuckler JM. Titanium serum and urine levels in rabbits with a titanium implant in the absence of wear. Biomaterials 1996;17:1937-42.

Williams DF, Adams D. A histochemical method for the determination of titanium in tissues surrounding 1976;29:657-61. J Clin Pathol

Williams D, Adams D, Mort E. A histochemical method for the detection of metals in tissues, with reference to the use of surgical implants. Microsc Acta 1978;81:1-7.

Frisken KW, Dandie GW, Lugowski S, Jordan G. A study of titanium release into body organs following the insertion of single threaded screw implants into the mandibles of sheep. Aust Dent J 2002;47:214-7.

Takamura K, Hayashi K, Ishinishi N, Yamada T, Sugioka Y. Evaluation of carcinogenicity and chronic toxicity associated with orthopedic implants in mice. J Biomed Mat Res 1994;28:583-9.

Rae T. The biological response to titanium and titanium-aluminum-vanadium alloy particles. I. Tissue culture studies. Biomaterials 1986;7:30- 6.

Sedarat C, Harmand MF, Naji A, Nowzari H. In vitro kinetic evaluation of titanium alloy biodegradation. J Periodontal Res 2001;36:269- 74.

Meyer U, Bühner M, Büchter A, Kruse-Löster B, Stamm T, Wiesmann HP. Fast element mapping of titanium wear around implants of different surface structures. Clin Oral Implants Res 2006;17:206-11.

Weingart D, Steinemann S, Schili W, Strub JR, Hellerich U, Assenmacher J, et al. Titanium deposition in regional lymph nodes after insertion of titanium screw implants in maxillofacial region. Int J Oral Maxillofac Surg 1994;23:450-2.

Morais LS, Serra GG, Palermo EFA, Andrade LR, Müller CA, Meyers MA, et al. Systemic levels of metallic ions released from orthodontic mini- implants. Am J Orthod Dentofacial Orthop 2009;135:522-9.

Sarmiento-González A, Marchante-Gayón JM, Tejerina-Lobo JM, Paz-Jiménez J, Sanz-Medel A. ICP-MS multielemental determination of metals potentially released from dental implants and articular prostheses in human biological fluids. Anal Bioanal Chem 2005;382:1001-9.

Sarmiento-González A, Marchante-Gayón JM, Tejerina-Lobo JM, Paz-Jiménez J, Sanz-Medel A. High-resolution ICP–MS determination of Ti, V, Cr, Co, Ni, and Mo in human blood and urine of patients implanted with a hip or knee prosthesis. Anal Bioanal Chem 2008;391:2583- 9.

Brown D. All you wanted to know about titanium, but were afraid to ask. Br Dent J 1997;182:393-4.

Guindy FS, Schiel H, Schmidli F, Wirz J. Corrosion at the marginal gap of implant- supported supra-structures and implant failure. Int J Oral Maxillofacial Imp 2004;19:826-31.

Olmedo DG, Tasat DR, Guglielmotti MB, Cabrini RL. Titanium transport through the blood stream. An experimental study on rats. J Mater Sci Mater Med 2003;14:1099-103.

Jacobs JJ, Skipor AK, Campbell A, Hallab NJ, Urban RM, Amstutz CJ. Can metal levels be used arthroplasties? Arthroplasty 2004;19:59-65.

Bianco PD, Ducheyne P, Cuckler JM. Systemic titanium levels in rabbits with a titanium implant in the absence of wear. J Mater Sci Mater Med 1997;8:525-9.

Sarmiento-González A, Encinar JR, Marchante- Gayón JM, Sanz-Medel A. Titanium levels in the organs and blood of rats with a titanium implant, in the absence of wear, as determined by double-focusing ICP-MS. Anal Bioanal Chem 2009;393:335-43.

Uzun G, Keyf F. İmplantların yüzey özellikleri ve osseointegrasyon. Atatürk Üniv Diş Hek Fak Derg 2007;Suppl 2:43-50.

Tsutsui T, Kawaguchi H, Fujino A, Sakai A, Kaji H, Nakamura T. Exposure of macrophage-like cells to titanium particles does not affect bone resorption, but inhibits bone formation. J Orthop Sci 1999;4:32-8.

Brayda-Bruno M, Fini M, Pierini G, Giavaresi G, Rocca M, Giardino R. Evaluation of systemic metal diffusion after spinal pedicular fixation with titanium alloy and stainless steel system: a 36-month experimental study in sheep. Int J Artif Organs 2001;24:41-9.

Hirose K, Isogai E, Miura H, Ueda I. Levels of porphyromonas inflammatory cytokines in gingival crevicular fluid from adult human subjects. Microbiol Immunol 1997;41:21-6. fimbriae and

Messer RL, Tackas G, Mickalonis J, Brown Y, Lewis JB, Wataha JC. Corrosion of machined titanium dental implants under inflammatory conditions. J Biomed Mater Res B Appl Biomater 2009;88:474-81.

Lee HJ, Kang IK, Chung CP, Choi SM. The subgingival microflora and gingival crevicular fluid cytokines in refractory periodontitis. J Clin Periodontol 1995;22:885-90.

Uematsu S, Deguchi T. Interleukin (IL)-1b, IL-6, Tumor necrosis factor-a, epidermal growth factor and beta2-microglobulin levels are elevated in gingival crevicular fluid during human orthodontic tooth movement. J Dent Res 1996;75:562-7.

Atilla G, Kutukculer N. Crevicular fluid interleukin-1b, tumor necrosis factor-alpha and interleukin-6 levels in renal transplant patients receiving cyclosporine A. J Periodontol 1998;69:784-90.